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KMID : 0351219920240040303
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Korean Journal of Infectious Diseases
1992 Volume.24 No. 4 p.303 ~ p.307
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Clinical Efficacy of Fluconazole in Oropharyngeal and Esophageal Candidiasis
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지종대
최철원/이구/유재명/김우주/김준석/박승철
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Abstract
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The incidence of fungal infections has increased because of a number of factors such as increasing prevalence of immune-compromised hosts associated with organ transplantation and malignancies, and increasing use of broad-spectrum antibiotics,
intravenous catheters, and hyperalimentation fluids.
Optimal therapies for fungal infections have not been defined. Amphotericin B is less than ideal because it is toxic, and can only be given intravenously. Ketoconazole is hepatotoxic and is less effective in the treatment of systemic fungal
infections.
Fluconazole is a new, triazole antifungal agent which is proving to be effective in a wide range of fungal infections.
Clinical study of fluconazole was undertaken to total 20 patients with oropharyngeal and esophageal candidiasis. Oral or intravenous fluconazole 50 to 100 mg once or twice daily were adminsterd. 17(85%) of 20 patients responded favorably to
treatment
and no adverse reactions occured. Mean duration of drug administration was 8.8 + 2.8 days and mean amount of drug administered was 955 + 627mg.
In conclusion, fluconazole is effective drug in the treatment of
oropharyngeal and esophageal candidiasis.
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KEYWORD
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